Interesting Stays
The most interesting Boutique Hotels I ever stayed at was the Dream Hotel in mid-town Manhattan. Compared to other hotels at that location it was affordable, and for me the ambiance was just stellar. Their regular rooms are pretty small, but the corner suites have spacious bay windows that afford spectacular views of Columbus Circle on one side and a glimpse of the Hudson River with glorious sunsets over it on the other. The high-tech blue lights under the bed theme with glass desktops in every room and charging stations for cell phones, laptops, etc., in every room also appealed to me.
The most different Bed and Breakfast I have yet to see is in Ventura, California, however, and it is a 110 year old church.